Hyperinsulinemia Drives Epithelial Tumorigenesis by Abrogating Cell Competition
نویسندگان
چکیده
منابع مشابه
Transient induction of ING4 by Myc drives prostate epithelial cell differentiation and its disruption drives prostate tumorigenesis.
The mechanisms by which Myc overexpression or Pten loss promotes prostate cancer development are poorly understood. We identified the chromatin remodeling protein, ING4, as a crucial switch downstream of Myc and Pten that is required for human prostate epithelial differentiation. Myc-induced transient expression of ING4 is required for the differentiation of basal epithelial cells into luminal ...
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The mechanisms by which Myc overexpression or Pten loss promotes prostate cancer development are poorly understood. We identified the chromatin remodeling protein, ING4, as a crucial switch downstream of Myc and Pten that is required for human prostate epithelial differentiation. Myc-induced transient expression of ING4 is required for the differentiation of basal epithelial cells into luminal ...
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ژورنال
عنوان ژورنال: Developmental Cell
سال: 2020
ISSN: 1534-5807
DOI: 10.1016/j.devcel.2020.04.008